Stem cells for the treatment of neoplastic and inflammatory diseasesAdult mammalian bone marrow contains two discrete populations of adult stem cells:
1) Hematopoietic stem cells, responsible for the continuous production of blood cells;
2) Bone marrow stromal cells or mesenchymal stem cells (MSC).
MSC are multipotent with the capacity to give rise to each of the differentiated cell lineages found in the marrow stroma, bone and cartilage; in culture, these cells have extensive differentiation potential to osteocytes, chondrocytes, adipocytes, neurons and myocytes. These properties, coupled with the apparent ease of ex vivo culture, have engendered considerable interest in potential therapeutic applications of these cells in a wide range of settings.
This project aims at understanding various aspects of MSC biology that may be relevant for their use in medicine, including basic aspects and therapeutic applications in pre-clinical and clinical studies, and the pathways that control hematopoietic stem cell differentiation.